Embryosafe is a line of tests for pre-implantation genetic diagnosis that, through embryonic biopsy, allows for reducing the risk of transferring and implanting an embryo with genetic abnormalities inherited from the parents, structural chromosomal aberrations, or aneuploidy.
The most limiting factor in assisted reproduction is, in fact, the failure of embryo implantation (responsible for over 72% of all failures), with the main cause being the presence of chromosomal abnormalities.
EMBRYOSAFE
Available panels
PGT-M
PGT-SR
PGT-A
EMBRYOSAFE
Who it's recommended for
EMBRYOSAFE
Analysis method
• Minisequencing single nucleotide mutations
• Fluorescent PCR small deletions/insertions
• Linkage analysis of complex genetic anomalies
NGS (Next Generation Sequencing).
NGS (Next Generation Sequencing).
Scientific publications in support
(1) Greco E, Minasi MG, Fiorentino F. Healthy babies born after intrauterine transfer of mosaic aneuploidy, blastocyst. N Engl J Med 2015; 373:2089-2090.
(2) Spinella F, Fiorentino F, Biricik A, et al. The extent of chromosomal mosaicism in"uences the clinical outcome of in vitro fertilization treatments. Fertil Steril 2018;109:77-83.
(3) Spinella F, Fiorentino F, Biricik A, Bono S, Ruberti A, Cotroneo E, Baldi M, Cursio E, Minasi MG, Greco E.
(4) Extent of chromosomal mosaicism in"uences the clinical outcome of in vitro fertilization treatments. Fertil Steril. 2018.
(5) Jan;109(1):77-83. doi: 10.1016/j.fertnstert.2017.09.025. Epub 2017 Nov 28. PMID: 29191449.
(6) Viotti M, Victor AR, Barnes FL, Zouves CG, Besser AG, Grifo JA, Cheng EH, Lee MS, Horcajadas JA, Corti L, Fiorentino F, Spinella F, Minasi MG, Greco E, Munné S.
(7) Using outcome data from one thousand mosaic embryo transfers to formulate an embryo ranking system for clinical use. Fertil Steril. 2021.